Crossword Clue:

to cause to be estranged or antagonized

AnswerCrossword Clue
HIDDENGEMMasterpiece waiting to be found ... or a hint to the words in the circled letters
CLEANUPResponse to 40-Across ... or what can be done to 12 answers in this puzzle without affecting their clues?
ENDEARCause to be cherished
BAFFLECause to be stuck
OSMOSECause to be absorbed
LATELUNCHOne may cause your dinner to be spoiled