| Answer | Crossword Clue |
|---|---|
| PALOS | Columbus's point of departure. |
| PALOS | Columbus's departure city: 1492 |
| PALOS | Columbus's starting point. |
| PALOS | Columbus's starting point |
| ESTE | Point on Columbus's compass |
| BASE | Point of departure |
| DOOR | Point of departure |
| START | Point of departure. |
| START | Point of departure |
| SPRINGBOARD | Point of departure |
| ONSET | Point of departure |
| ETAH | Greenland point of departure for explorers. |
| IDEA | "A point of departure and no more": Picasso |
| LAE | New Guinea port that was Amelia Earhart's last known point of departure |
| inbound | Traveling toward a particular place, esp. when returning to the original point of departure |
