| Answer | Crossword Clue |
|---|---|
| AGONY | It's a big pain |
| ACHE | It's a pain |
| AGONY | It's a major pain |
| OTITIS | It's a pain in the ear |
| methadon | a synthetic addictive narcotic drug C21H27NO used especially in the form of its hydrochloride for the relief of pain and as a substitute narcotic in the treatment of heroin addiction |
| HEADACHE | Big pain |
| EARACHE | Big pain for an elephant? |
| ANNOYED | Gave Andy one big pain |
| ALEVE | Big name in pain relief |
| DRACULA | Big pain in the neck? |
| MOTRIN | Big name in pain relief |
