Crossword Clue:

Need to make a difference

Answer	Crossword Clue
MINUSSIGN	Need to make a difference
AFFECT	Make a difference to
CHANGETHEWORLD	Make a difference, so to speak

MINUSSIGN	It's needed to make a difference
SUBSTITUTION	"The pizzeria's out of mushrooms, though, so he'll need to make a ..."
OWE	Need to make payments
TEST	You need it to make the grade
SPAT	You need this to kiss and make up
APIT	"Anybody need to make ... stop?" (road trip query)