Crossword Clue:

by the route of through

AnswerCrossword Clue
BYROADRoute through the boondocks
PASSRoute through the Rockies
INCAThe ... Trail (route through Peru)
NOLOOKPASSAcrophobe's term for a route through the mountains?
KHYBERPASSMountainous route once used by Alexander the Great
PLATTERiver paralleled by I-80 through a long stretch of the Plains