Answer:

AFIRST

AnswerCrossword Clue
AFIRST"There's .. time for everything"
AFIRSTSomething new
AFIRSTSomething original
AFIRSTSomething unprecedented
AFIRST"This is totally new!"
AFIRSTIt hasn't happened before
AFIRSTSomething groundbreaking
AFIRST"That's ...!" ("Never seen that before!")
AFIRSTSomething novel
AFIRSTWhat sending someone to Mars would be
AFIRSTSomething record-breaking