Answer:

LOCO

AnswerCrossword Clue
LOCOIn .. parentis
LOCOInsane
LOCOWeed or motive starter
LOCOPlumb crazy
LOCOTouched
LOCOOff one's trolley
LOCOCrazy, in Texas
LOCOBats
LOCOBonkers
LOCOCrackers or nuts
LOCOBananas
LOCOHaywire
LOCOIn ... parentis
LOCOBerserk
LOCOIn ... parentis: acting as a parent
LOCOMad
LOCOOff one's rocker
LOCOTouched in the head
LOCONot all there
LOCOCrazy as a loon
LOCONuts
LOCOScrewy
LOCODaffy
LOCONuts or crackers?
LOCOCrackers
LOCOOff one's rocker, and a hint to what the four longest puzzle answers have in common
LOCONot right in the head
LOCOOut of one's gourd
LOCOPrefix with weed or motion
LOCOBats or bonkers
LOCOOff your rocker
LOCOCrazy, in Cozumel
LOCOCrazy
LOCOIn ... parentis (acting as mom or pop)
LOCOBananas, nuts, or crackers
LOCOCrazy in la cabeza
LOCOCuckoo, in CancĂșn
LOCOWacky
LOCOCrazy, in CancĂșn
LOCOCuckoo