Answer:

MAJOR

AnswerCrossword Clue
MAJORFrank Burns, for example
MAJORImportant
MAJOR.... League
MAJORNot minor
MAJORLabel one might be called a sellout for signing with
MAJORMain course?
MAJORCollegian's specialty
MAJORStudent's specialty
MAJORThatcher's successor
MAJOREducation declaration
MAJORAcademic focus
MAJORStudent's declaration
MAJORExtensive
MAJORComparative literature, e.g.
MAJORStudent's focus
MAJORMilitary bigwig
MAJORStudent's choice
MAJORComputer science, e.g.
MAJORGold oak leaf wearer
MAJORCollegian's focus
MAJORCaptain's superior
MAJORCollege declaration
MAJORCollege choice
MAJORBlair's predecessor
MAJORCollege concentration
MAJORCollegian's focus subject
MAJORSignificant
MAJOR"... League" (Tom Berenger comedy)
MAJORCollegian's decision
MAJORBarbara or Bowes
MAJORCollege field of study
MAJORRank for "Hot Lips"
MAJORBlair is his heir
MAJORVery important
MAJORCollegian's selection
MAJORHot Lips Houlihan's rank
MAJORPrincipal field of study
MAJORThe U.S. Open or the Masters
MAJORBig-time
MAJORProminent