Answer:

PAIN

Answer	Crossword Clue
PAIN	Agony
PAIN	Pesky kid
PAIN	Soreness

PAIN	Advil target
PAIN	"No ..., no gain"
PAIN	Pesky kid, e.g.
PAIN	Gain prerequisite
PAIN	Botheration
PAIN	Ache
PAIN	Nuisance
PAIN	Analgesic's target

PAIN	Arduous chore
PAIN	French bread
PAIN	Ibuprofen target
PAIN	Discomfort
PAIN	Reason to take butorphanol
PAIN	"... forces even the innocent to lie": Publilius Syrus
PAIN	Annoyance
PAIN	Distress

PAIN	Hurt
PAIN	"Royal" annoyance
PAIN	Anguish
PAIN	Tylenol target
PAIN	Tylenol's target
PAIN	Aleve target
PAIN	Partner of suffering
PAIN	Pest

PAIN	"Royal" nuisance
PAIN	It can be chronic or shooting
PAIN	"No .., no gain"
PAIN	Aspirin target
PAIN	"I feel your .."
PAIN	"King of ..." ('83 hit for the Police)
PAIN	Analgesic target
PAIN	Aspirin's target

PAIN	Gain prerequisite?
PAIN	Suffering partner?
PAIN	Reason to take acetaminophen
PAIN	Neck ailment?
PAIN	Annoying person