Answer:

UNO

AnswerCrossword Clue
UNOPopular card game
UNOFiat model
UNONumero ..
UNONumero ...
UNONumero .. (first-rate)
UNOOpening word of "Wooly Bully"
UNOFamily card game
UNOKid's card game
UNOChicago Grill Pizzeria
UNOCard game with reverses and skips
UNOChicago pizza chain
UNOGame with a Wild card
UNOGame with Skip and Reverse cards
UNOPizza chain with a Chicago name but a Boston headquarters
UNOGame with 108 cards
UNOWild Draw Four game
UNOJuan's "one"
UNOOne for the Spanish
UNOItalian's one
UNO"Wooly Bully" opener
UNOMattel card game
UNOFirst digit, in Milan
UNOTop numero
UNOHalf of dos
UNOArticle in Spanish
UNOCard-shedding game
UNOColorful card game
UNOLow numero
UNOStart of a cuenta
UNOGame with a 108-card deck
UNOIt's not quite due?
UNOGame akin to crazy eights
UNOItalian one
UNONumero after cero
UNOEx ... omnes (generalization principle)
UNOGame with wild cards
UNOCinco minus cuatro
UNOGame similar to crazy eights
UNOCard game similar to Mau Mau
UNOForeign article