Its brightest star is Spica
Crossword Clue

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AnswerCrossword Clue
VIRGOIts brightest star is Spica
LEORegulus is its brightest star
LYRAVega is its brightest star
LEOIts brightest star is Regulus
LEOConstellation whose brightest star is Regulus
RIGELABrightest star in Orion, which is part of a binary system with a much fainter B star