| Answer | Crossword Clue |
|---|---|
| PILL | Major pain, slangily |
| PILL | Major pain |
| HASSLE | Major pain |
| AGONY | Major pain |
| AGONY | It's a major pain |
| BIGS | Major leagues, slangily |
| BAG | Major interest, slangily |
| ECON | College major, slangily |
| BIGS | Major league, slangily |
| BIGONE | Major natural disaster, slangily |
| BIGS | Major leagues, slangily, with "the" |
