| Answer | Crossword Clue |
|---|---|
| PIKE | Major route |
| ARTERY | Major route |
| ARTERY | Major transportation route |
| ORTRAIL | Major overland migration route |
| CHISHOLMTRAIL | Major Old West cattle route |
| ITEN | Major Calif.-to-Fla. route |
| ITEN | Major Fla.-to-Calif. route |
| IEIGHTYONE | Major New York-to-Tennessee route |
| waypoint | a point between major points on a route |
| waypoints | WAYPOINT, a point between major points on a route |
