| Answer | Crossword Clue |
|---|---|
| CHISHOLMTRAIL | Old West route |
| CHISHOLMTRAIL | Major Old West cattle route |
| SOUTHERN | Route to Key West. |
| ITEN | Route west of Jacksonville, Fla. |
| PANAM | Its first route was Key West-Havana |
| SCENIC | Like the West Coast's U.S. Route 101 |
| IFYOU | "... ever plan to motor west..." ("Route 66" intro) |
