One instrumental in music history?
Crossword Clue

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AnswerCrossword Clue
AMATI

One instrumental in music history?

AMATI

One instrumental in history?

FUZZGUITAR

One is featured in the 1962 Ventures instrumental "The 2,000 Pound Bee"

ITUNES
Apple's all-in-one music player
TROMBONE
One of 76 in a "Music Man" song
STEPWISEFrom one tone to the next, in music
MODULATEShift from one key to another, in music.
REMBREAKUP2011 headline in music news (I know one of them quit years ago; sue me for preferring the classic lineup)