Procedural that aired its 250th episode in 2011
Crossword Clue

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AnswerCrossword Clue
CSIProcedural that aired its 250th episode in 2011
SIMPSONS"The ..," sitcom that recently aired its 250th episode
LOSTSeries that aired its final episode in May 2010
WHOThe .. (rock band that lent its voices to 15-Across's 250th episode)