Answer: aggravation

AnswerCrossword Clue
aggravationan act or circumstance that intensifies or makes worse
aggravationAn intensification of a negative quality or aspect
aggravationThe state of being aggravated
aggravation(in homeopathy) The temporary appearance or worsening of symptoms that a remedy is intended to eliminated, taken to be caused by too strong a dose
aggravationA cause of annoyance or irritation