Answer: blowit

AnswerCrossword Clue
BLOWIT

Mess up

BLOWIT

Botch the opportunity

BLOWIT

Botch the job

BLOWIT
Totally screw up
BLOWIT
Mess up a good opportunity
BLOWITScrew up
BLOWITLose when you should have won, and a hint to the start of the answers to starred clues
BLOWITMiscalculate
BLOWITBlunder
BLOWITFail big-time
BLOWITTotally fail
BLOWITLouse up
BLOWITGoof