Answer: blowit

AnswerCrossword Clue
BLOWITMess up
BLOWITBotch the opportunity
BLOWITBotch the job
BLOWITTotally screw up
BLOWITMess up a good opportunity
BLOWITScrew up
BLOWITLose when you should have won, and a hint to the start of the answers to starred clues
BLOWITMiscalculate
BLOWITBlunder
BLOWITFail big-time
BLOWITTotally fail
BLOWITLouse up
BLOWITGoof