Answer: commerce

AnswerCrossword Clue
COMMERCEInterstate activity
COMMERCETrade
COMMERCECabinet post.
COMMERCETraffic.
COMMERCECabinet office
COMMERCESocial intercourse
COMMERCECabinet department
commerceThe activity of buying and selling, esp. on a large scale
commerceto trade (to have dealing with)
commerceSocial dealings between people
commerceSexual intercourse