Answer: decompensation

AnswerCrossword Clue
decompensationthe failure of an organ to cope with increasing demands made on it owing to disease
decompensationThe failure to generate effective psychological coping mechanisms in response to stress, resulting in personality disturbance or disintegration, esp. that which causes relapse in schizophrenia
decompensationThe failure of an organ (esp. the liver or heart) to compensate for the functional overload resulting from disease