Answer: despair

AnswerCrossword Clue
DESPAIRHeartache
DESPAIRLoss of hope.
DESPAIR"Shall I wasting in ... . . . "
DESPAIRPostloss reaction, sometimes
DESPAIRFilm noir feature
DESPAIRBad thing to sink into
DESPAIRLow state
DESPAIR"The shadow of a starless night," per Percy Bysshe Shelley
DESPAIR..., Inc. (company that sells demotivational posters)
DESPAIRGiant who lives in Doubting Castle.
DESPAIRGloom
DESPAIRGrief
DESPAIRHopeless
DESPAIRFeeling of hopelessness
despairto lose all hope
despairhopelessness or a cause of hopelessness
despairto lose hope
DESPAIRGive up all hope
DESPAIRSlough of despond.
DESPAIRGiant of Doubting Castle.
DESPAIRGiant in "Pilgrim's Progress."
DESPAIRGiant in Pilgrim's Progress.
DESPAIRLose all hope
DESPAIRGive up
DESPAIRLoss of hope
DESPAIRHopelessness
DESPAIRVery blue state
DESPAIRLose heart
DESPAIRDown state
DESPAIRHopeless feeling
DESPAIRAbandon hope
DESPAIRGive up hope
DESPAIRLose hope