Answer: despite

AnswerCrossword Clue
DESPITEEven considering
DESPITERegardless of
DESPITENotwithstanding
DESPITEDisregarding
DESPITEIn the face of
DESPITENotwithstanding.
DESPITENevertheless.
DESPITEInsult
DESPITEEven with
despiteto treat with contempt
despiteWithout being affected by; in spite of