Answer: despond

AnswerCrossword Clue
DESPONDIn the Slough of ... (depressed)
DESPONDThe slough of ....
DESPONDBecome disheartened.
DESPONDBunyan's Slough of ....
DESPONDSlough of ...
DESPONDLose heart
DESPONDFeel extreme discouragement
despondto be depressed by loss of hope, confidence, or courage
despondstate of being depressed in spirit, as from loss of courage or hope; dejection
despondto lose heart