Answer: despond

AnswerCrossword Clue
DESPOND

In the Slough of ... (depressed)

DESPOND

The slough of ....

DESPOND

Become disheartened.

DESPOND
Bunyan's Slough of ....
DESPOND
Slough of ...
DESPONDLose heart
DESPONDFeel extreme discouragement