Answer:

estranged

Answer	Crossword Clue
ESTRANGED	Turned against
ESTRANGED	Turned hostile
ESTRANGED	On the outs

ESTRANGED	No longer on speaking terms
ESTRANGED	No longer close
ESTRANGED	Separated
ESTRANGED	Alienated
ESTRANGED	Alienated.
ESTRANGED	Friends no more.
ESTRANGED	Disaffected.
ESTRANGED	On the outs with

ESTRANGED	Removed from usual surroundings