Answer:

holiest

Answer	Crossword Clue
HOLIEST	Most saintly
HOLIEST	Most sacred
HOLIEST	Most divine

HOLIEST	The most blessed.
HOLIEST	Most revered
HOLIEST	Least profane
HOLIEST	The Pope, among Catholics

Crossword

a puzzle consisting of a grid of squares and blanks into which words crossing vertically and horizontally are written according to clues.