Answer: irritation

AnswerCrossword Clue
IRRITATIONThorn in one's side
IRRITATIONAnnoyance
IRRITATIONPain in the neck
IRRITATIONThe pea, in "The Princess and the Pea"
IRRITATIONPique condition
irritationThe stimulation of an organism, cell, or organ to produce an active response
irritationThe state of feeling annoyed, impatient, or angry
irritationthe act of irritating
irritationThe production of inflammation or other discomfort in a bodily part or organ
irritationA cause of this