Answer: littlest

AnswerCrossword Clue
LITTLESTThe ... Angel
LITTLESTLike the runt
LITTLESTLike runts
LITTLESTMost petite
LITTLEST"The ... Rebel," S. Temple film
LITTLESTLeast important
LITTLESTLeast large
LITTLESTAdjective for a runt
littlestRelatively unimportant; trivial (often used ironically)
littlestSmall in size, amount, or degree (often used to convey an appealing diminutiveness or express an affectionate or condescending attitude)
littlest(of a person) Young or younger
littlestDenoting something, esp. a place, that is named after a similar larger one
littlestUsed in names of animals and plants that are smaller than related kinds, e.g., little grebe
littlestLITTLE, small (little in size)
littlestOf short distance or duration