Answer: maddest

AnswerCrossword Clue
MADDESTMost harebrained
MADDESTMost miffed
MADDESTMost irritated
MADDESTMost frenzied
MADDESTTops in soreness
MADDESTMost impractical.
MADDESTMost like a hatter
MADDESTCrossest
maddestMAD, insane (mentally unsound)
maddestinsane
maddestviolent
maddestangry