Answer: opium

AnswerCrossword Clue
OPIUM

It may be found in a den

OPIUM

"Confessions of an English ...-Eater"

OPIUM

Yves Saint Laurent fragrance

OPIUM
Painkiller since ancient times
OPIUM
Drug that's smoked in a pipe
OPIUMSmuggler's stock
OPIUMSmuggled stuff
OPIUMKind of pipe
OPIUMIt's addictive
OPIUMDrug from poppies
OPIUMReligion, to Karl Marx
OPIUMDope in a den?
OPIUMPainkiller
OPIUMYves St. Laurent fragrance
OPIUMCause of an 1839-42 war
OPIUMSoutheast Asia product
OPIUMDried poppy juice
OPIUMWhat De Quincey ate
OPIUMDrug made from poppies
OPIUMYves Saint Laurent perfume since 1977
OPIUMPerfume from YSL
OPIUM.. War of 1839-42
OPIUMDrug served in a den
OPIUMAfghanistan crop
OPIUMDen drug of old
OPIUMNarcotic from a poppy
OPIUMDrug once smoked in dens
OPIUMDe Quincey subject
OPIUMDrug in the den?
OPIUMSource of codeine
OPIUMSaint Laurent fragrance
OPIUMDrug that may be taken in tea
OPIUMYSL perfume named for a drug
OPIUMHeroin source
OPIUMVice of Dorian Gray
OPIUMPoppy derivative
OPIUMHookah substance
OPIUMCause of 19th century warfare between England and China
OPIUMPoppy-based narcotic
OPIUMFocus of an 1839-42 war