Answer: outwest

AnswerCrossword Clue
OUTWESTWhere many homesteaders headed
OUTWESTOpposite of "back east"
OUTWESTWhere many pioneers headed
OUTWESTWhere buffalo roam
OUTWESTWhere some old trails ended
OUTWESTWhere the dogies roam
OUTWESTWhere many American pioneers settled