Answer:

surest

Answer	Crossword Clue
SUREST	"The .. poison is time.": Emerson
SUREST	"The .. poison is time....": Emerson
SUREST	Most certain

SUREST	Most reliable
SUREST	Superlatively self-confident
SUREST	Most dependable
SUREST	Most likely
SUREST	Most confident
SUREST	Like the best bet
SUREST	Most convinced
SUREST	Most definite

SUREST	Least iffy
SUREST	Most likely to succeed
SUREST	Most infallible.
SUREST	Most reliable.
SUREST	Most confident.
SUREST	Most stable.
SUREST	Most certain.
SUREST	Most dependable.

SUREST	Most trustworthy.
SUREST	Most positive.
SUREST	Most positive
SUREST	"... thing you know"
SUREST	Least doubtful
SUREST	Least equivocal
SUREST	Least vacillating
SUREST	Like the risk to bet on, maybe

SUREST	Optimal, as a bet
SUREST	Superlatively decided
SUREST	Most indisputable
SUREST	Best, as a bet
SUREST	Most likely to work
SUREST	Least dubious
SUREST	Having the best hands
SUREST	Least in question