Answer: tranquilize

AnswerCrossword Clue
TRANQUILIZEQuiet down.
TRANQUILIZECalm.
TRANQUILIZESoothe
tranquilize(of a drug) Have a calming or sedative effect on
tranquilizeto make tranquil or calm
tranquilizeMake tranquil
tranquilizeAdminister such a drug to (a person or animal)