Answer: upsanddowns

AnswerCrossword Clue
UPSANDDOWNS

Vagaries

UPSANDDOWNS

Twists of fortune

UPSANDDOWNS

Good and bad times

UPSANDDOWNS
Extremes of life's happenings
UPSANDDOWNS
Vicissitudes.
UPSANDDOWNSBusiness trends
UPSANDDOWNSVicissitudes
UPSANDDOWNSVicissitudes of life, as for the inventor named in the circled squares?
UPSANDDOWNSGood times and bad
UPSANDDOWNSFickleness of life