Answer: upsanddowns

AnswerCrossword Clue
UPSANDDOWNSVagaries
UPSANDDOWNSTwists of fortune
UPSANDDOWNSGood and bad times
UPSANDDOWNSExtremes of life's happenings
UPSANDDOWNSVicissitudes.
UPSANDDOWNSBusiness trends
UPSANDDOWNSVicissitudes
UPSANDDOWNSVicissitudes of life, as for the inventor named in the circled squares?
UPSANDDOWNSGood times and bad
UPSANDDOWNSFickleness of life