Answer: vicissitude

AnswerCrossword Clue
VICISSITUDEIrregular change.
VICISSITUDEOne of the ups and downs of fortune.
vicissitudea change or variation occurring in the course of something.
vicissitudeAlternation between opposite or contrasting things
vicissitudea change of circumstances affecting one's life
vicissitudeA change of circumstances or fortune, typically one that is unwelcome or unpleasant