Answer: worry

AnswerCrossword Clue
WORRYLose sleep over (with "about")
WORRYCause of wrinkles
WORRY"Interest paid on trouble before it falls due," per W. R. Inge
WORRYCause of fitful sleep
WORRYProducer of wrinkles, it's said
WORRY"What, me ...?": Alfred E. Neuman line
WORRYLose sleep over
WORRYDistress
WORRYKind of beads
WORRYShow concern
WORRY"What, me ...?"
WORRYBe in a fretful mood
worryto feel anxious
worryto progress or succeed by constant effort, despite difficulty
worryanxiety
worrycause of anxiety
worryto cause to be anxious
worryto seize with the teeth and shake
worryto make anxious
WORRYVexation.
WORRYIt "often gives a small thing a big shadow": old proverb
WORRYFret
WORRY"What, me ...?" (Mad magazine motto)
WORRYEnd of Alfred E. Neuman's slogan
WORRYStew
WORRYAnxiety
WORRYBe fretful
WORRYGray hair dye.
WORRYCare.
WORRYLose sleep
WORRYBother.
WORRYFret.
WORRYAngst.
WORRYFret or chafe
WORRYTopic of quotation below
WORRYTrouble
WORRYConcern
WORRYDog or hound