| Answer | Crossword Clue |
|---|---|
| INGENUE | Young female lead |
| ROSE | "Titanic" female lead |
| FIONA | Female lead in "Brigadoon" |
| ANNA | "The King and I" female lead |
| NALA | Female lead in The Lion King |
| CIS | Lead-in to male or female |
| LASSIE | Female lead played only by males |
| UMATHURMAN | Female lead in "Gattaca" and "Kill Bill" |
| ADELE | First female singer to have three simultaneous top 10 hits as a lead artist |
